For multiple or simultaneous arylations of aryl boronic acids, a protocol was developed by utilizing the site-specific protection strategy of Karlin and co-workers and the Pd-mediated trifluorination protocol of Toste (Figure 9). Protection of the aryl boronic acid, forming the corresponding trifluorinated boronic acid, followed by arylation of the protected boronic acid with aryl halides gave access to a diverse range of arylated boronic acid derivatives. This was achieved in a simple and efficient two-step protocol.
The current work provides the foundation for the rapid development of arylated boronic acids and represents an attractive strategy for the synthesis of pharmaceutical intermediates.
The amino-quinoline scaffold has attracted considerable attention for its structure activity relationships (SAR) against a wide range of biological targets, including several important human protein kinases.1-5 The current work describes a rapid and scalable approach for the synthesis of a wide variety of orthogonally protected amino-quinoline building blocks.
Arylation of the difluoro-boronic acid was achieved by a deprotection/trifluorination protocol. The boronic acid can be prepared via the boronic acid-catalyzed arylation of an activated isocyanide using a variety of aryl halides in moderate to good yield. The trifluorinated intermediate was isolated and used in the next step.
Boronic acids are privileged scaffolds that have found numerous applications in the pharmaceutical industry. In recent years, they have become increasingly attractive owing to their use in asymmetric synthesis, which typically occurs via a cationic palladium-catalyzed arylation of a difluoro-boronic acid.1,2 While efficient, these reactions typically require the use of stoichiometric amounts of palladium catalysts, which can be costly and challenging to handle. Moreover, the conditions involved are often incompatible with sensitive functional groups, such as arenesulfonyl chlorides, which are commonly employed in the formation of aryl chlorides.1-3 We hypothesized that a protocol would be developed that would provide the required trifluorinated aryl boronic acid under mild conditions in good yield.
The synthetic routes for the synthesis of enantiomerically enriched amino-quinoline derivatives are known, but 01e38acffe
Investigations of the structures of surfactants and polymers are key to understanding how they meditate the properties of the .
Opportunities in polymer science and technology: evaluation of structures and properties of polymers and non-polymers in the form of chemical structures provides essential information and constraints that support engineering design of new products and processes.
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Opportunities in polymer science and technology: evaluation of structures and properties of polymers and non-polymers in the form of chemical structures provides essential information and constraints that support engineering design of new products and processes.
Opportunities in polymer science and technology: evaluation of structures and properties of polymers and non-polymers in the form of chemical structures provides essential information and constraints that support engineering design of new products and processes.Bethany F.C.
Bethany Football Club is a professional football club based in Plumstead, London. The team currently plays in the.
History
The club was founded in 2006 as a successor to the 2000–01 Home Counties League club Bethany Town. The team was admitted into the Spartan South Midlands League in the 2006–07 season and a year later were renamed Bethany-Fryenham in a sponsorship deal with Foam Plastics. At the end of the 2007–08 season, they were transferred to the South Midlands Football League, where they would play until the end of the 2008–09 season. In the summer of 2009, the club moved up to the Isthmian League, after winning the South Midlands League.
In the 2010–11 season, the club were renamed Bethany Town Sports and moved to Thamesmead. They were renamed again the following season, moving to Bromley. The club's final season in the South Midlands League saw them play at Bethnal Green's Victoria Park Stadium. After failing to gain promotion in the 2011–12 season, the club were wound up.
In 2013, Bethany Football Club was reformed and joined the Kent County League, where they played until joining the Spartan South Midlands League in 2015. The following season saw the club stay in the division for one season before moving up to the Kent League in 2017. In 2017–18, Bethany won the Kent Senior Cup, beating Edenbridge in the final.
Colours and badge
The team's colours are red and blue.
Stadium
Bethany play their home games at The Lanih
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